… petite mutants has also been noted in clinical samples obtained from patients infected with
Candida glabrata … lacking PDR1 mutations were selected and analyzed further for petite traits. …

… rendering strains avirulent, we used an in vivo Galleria … trait, we selected genes that were
mutated at least twice … CDR1 have already been reported in azole-resistant strains,33,34 and …

… Additionally, the absence of ERG11 gene mutations and … in the development of azole-resistant
C. tropicalis are warranted. … a possibility of treatment failure in vivo in patients having prior …

… glabrata and C. albicans. Compared to the reference drugs (… yeast species and generated
fewer petite mutants. Moreover, … distinct media, petite mutants could be selected. To confirm …

… These results indicate that the petite mutant can emerge during C. glabrata infections in vivo
… mitochondrial protein that is upregulated by Pdr1 in azole-resistant strains (23). We did not …

… , drug-resistant Candida and their petite mutants remain a major … Select quadrants with
5-80 colonies from the previously chosen … glabrata (C2-1000907) petite mutants with impaired …

… In the azole-resistant strain derived from the CBS138 strain, CBS138_Psc, a mutation in the
… GOF mutations, induced by drug exposure, natural selection favours cells harbouring these …

… glabrata, several studies suggest that mutations in ERG11 … ) and incompetence (azole-resistant)
in response to azole … glabrata resistant isolates was demonstrated in vivo by others […

… Certain mutations occur frequently in vivo, eg. in genes … The slow growth of petite mutants
limits their identification in the … CgMIP1, has been under positive selection. Here it is shown that …

… glabrata strain with a single nucleotide mutation in the chitin … growth under both in vitro
and in vivo iron-limiting conditions. The … Some alterations are exclusively found in azole-resistant …